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Over-vaccination in pets can lead to an increased likelihood of allergic reactions. When pets receive vaccines that their immune systems are not adequately prepared to handle, it can create an excessive immune response, leading to adverse effects. Allergic reactions may manifest in various ways, such as skin irritations, gastrointestinal issues, or even more severe systemic reactions. Recognizing the potential for these side effects underscores the importance of following recommended vaccination schedules and consulting with a veterinarian to determine the appropriate vaccinations based on an individual pet's health needs.

Enhanced immune response, improved long-term health, and greater resistance to diseases are typically viewed as beneficial outcomes of vaccination when administered appropriately. However, when vaccinations are given excessively, these positive effects can be overshadowed by the negative consequences of the immune system being overstimulated, highlighting the need for a balanced and individualized approach to vaccination in pets.